Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHP) is the result of excessive, independent, and inappropriate production of parathyroid hormone (PTH). The aim of this work is to study the epidemiological, clinico-biological and therapeutic aspects of PHP.Materials and methods: This is a retrospective study of 34 patients hospitalized for the management of PHP in the Endocrinology Department of the Military Hospital of Tunis between March 1999 and July 2018....

Abstract: Brown tumors also known as osteitis fibrosa are a very rare complications of primary hyperparathyroism that occur in less than 2% of patients suffering from any form of hyperparathyroidism. Parathormone increases osteoclastic activity in the bones causing cystic bony changes, it’s a reparative cellular process. Common sites of brown tumor are the ribs, clavicle, long bones and pelvic girdle. Our case is 55 years old tunisian men who was admitted to orthopedic de...

Introduction: The ectopic posterior pituitary is a rare condition which is characterized by the ectopic location of posterior lobe of pituitary, pituitary stalk abnormalities, and associated clinical manifestations of anterior lobe related growth hormone dysfunction or less commonly multiple anterior pituitary dysfunctions. We describe the case of a young female who presented with short stature and was found to have ectopic posterior pituitary.Case prese...

Introduction: Hyponatremia represents a frequent electrolyte disorder. It is defined as a serum sodium level below 135 mmol/L and it is severe when serum level is below 125 mmol/l. Endocrine disorders including adrenal deficiency and hypothyroidism are uncommon causes of hyponatremia. Secondary adrenal insufficiency is related with hyponatremia through increased ADH secretion.Herein, we report a case of severe hyponatremia revealing hypopituitarism.<...

Introduction: Adrenocortical carcinoma (ACC) is a rare aggressive endocrine neoplasm. It’s a heterogeneous malignant tumor with incompletely understood pathogenesis and poor prognosis. The aim of our study was to assess clinical and paraclinical characteristics of ACC and to determine its outcome.Methods: In a retrospective and descriptive study, we included patients with adrenocortical carcinoma confirmed with histopathological examination. Clinic...

Introduction: Diabetes is a disease that can slowly be. Among its complications, erectile dysfunction can appear. Be careful, these problems can be warning signs. These problems can be warning signs, especially cardiovascular, but they also have significant psychological retention.Materials and methods: Prospective study on 37 diabetic patients collegiate in the department of Endocrinology CHU Hedi Chaker Sfax Tunisia. All patients are assessed for erect...

Introduction: Sarcoidosis affects both the central and peripheral nervous system in 5–16% of patients. In most cases, such involvement occurs within a multi-systemic disease. Endocrine manifestations of neurosarcoidosis can be expressed by hypothalamic dysfunction, diabetes insipidus, hypopituitarism, hyperprolactinemia, in isolated fashion or variedly combined.Herein, we report a case of neurosarcoidosis revealed by an obstructive hydrocephalus, a...

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushing’s syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...

Introduction: In adults with Addison disease, over glucocorticoid replacement therapy is associated with an increased morbidity and decreased life expectancy, related to low bone mineral density and cardiometabolic outcomes. The aim of our study was to assess the prevalence of carbohydrate metabolism disorders in patients with Addison disease and identify its predictive factors.Patients and methods: A cross sectional study including 50 patients diagnosed...

Introduction: Because of a long-term glucocorticoid replacement over many years, patients with Addison disease may have an increased occurrence of osteoporosis. Furthermore, the prevalence of osteoporosis in patients with Addison disease may also be increased because of premature menopause associated autoimmune endocrinopathies and hypovitaminosis D.The objective of this study is to assess the incidence and risk factors for osteoporosis among patients with Addison disease....